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Article

PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.

International journal of cancer - 1 Sept 2014

Xiao Jianqiao, Lee Seung-Tae, Xiao Yuanyuan, Ma Xiaomei, Houseman E Andres, Hsu Ling-I, Roy Ritu, Wrensch Margaret, de Smith Adam J, Chokkalingam Anand, Buffler Patricia, Wiencke John K, Wiemels Joseph L

Abstract excerpt

While the cytogenetic and genetic characteristics of childhood acute lymphoblastic leukemias (ALL) are well studied, less clearly understood are the contributing epigenetic mechanisms that influence the leukemia phenotype. Our previous studies and others identified gene mutation (RAS) and DNA methylation (FHIT) to be associated with the most common cytogenetic subgroup of childhood ALL, high hyperdiploidy (having...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Extracellular Signal-Regulated MAP Kinases

Share to Gene Expression Regulation, Leukemic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 24496747
DOI: 10.1002/ijc.28759
PMCID: PMC4776754

Genes

PTPRG
FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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