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Article

Epigenetic deregulation in pediatric acute lymphoblastic leukemia

6 Jan 2014

Abstract excerpt

Similar to most cancers, genome-wide DNA methylation profiles are commonly altered in pediatric acute lymphoblastic leukemia (ALL); however, recent observations highlight that a large portion of malignancy-associated DNA methylation alterations are not accompanied by related gene expression changes. By analyzing and integrating the methylome and transcriptome profiles of pediatric B-cell ALL cases and primary...

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PMID: 24394348
DOI: 10.4161/epi.27585

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