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Article

EZH2 mutations and promoter hypermethylation in childhood acute lymphoblastic leukemia.

Journal of cancer research and clinical oncology - 1 Jul 2016

Schäfer Vivien, Ernst Jana, Rinke Jenny, Winkelmann Nils, Beck James F, Hochhaus Andreas, Gruhn Bernd, Ernst Thomas

Abstract excerpt

PURPOSE: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and young adults. The polycomb repressive complex 2 (PRC2) has been identified as one of the most frequently mutated epigenetic protein complexes in hematologic cancers. PRC2 acts as an epigenetic repressor through histone H3 lysine 27 trimethylation (H3K27me3), catalyzed by the histone methyltransferase enhancer of zeste...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enhancer of Zeste Homolog 2 Protein

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 27169594
DOI: 10.1007/s00432-016-2174-8

Genes

EED
SUZ12
ASXL1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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