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Article

Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes

1 Jan 2007

Abstract excerpt

The hallmark of acute lymphoblastic leukemia (ALL) is a progressive appearance of malignant cell behavior that is triggered by the evolution of altered gene function. ALL has traditionally been viewed as a genetic disease; however, epigenetic defects also play an important role. DNA promoter methylation has gained increasing recognition as an important mechanism for transcriptional silencing of tumor-suppressor...

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PMID: 17613754
DOI: 10.1080/10428190701344899

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