Genome‐wide <scp>DNA</scp> methylation profiling predicts relapse in childhood B‐cell acute lymphoblastic leukaemia

Abstract excerpt

Although the five-year survival of childhood acute lymphoblastic leukaemia (ALL) exceeds 80%, a group of patients presents poor prognosis due to early relapse (van den Berg et al, 2011). To date, treatment strategies have been defined by cytogenetically-based subtype categorization. However, ALL patients without chromosomal translocations associated with poor prognosis lack diagnostic markers that would allow...

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