Article
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Genes & development - 1 Feb 2014
Sheean Maria E, McShane Erik, Cheret Cyril, Walcher Jan, Müller Thomas, Wulf-Goldenberg Annika, Hoelper Soraya, Garratt Alistair N, Krüger Markus, Rajewsky Klaus, Meijer Dies, Birchmeier Walter, Lewin Gary R, Selbach Matthias, Birchmeier Carmen
Abstract excerpt
Myelination depends on the synthesis of large amounts of myelin transcripts and proteins and is controlled by Nrg1/ErbB/Shp2 signaling. We developed a novel pulse labeling strategy based on stable isotope labeling with amino acids in cell culture (SILAC) to measure the dynamics of myelin protein production in mice. We found that protein synthesis is dampened in the maturing postnatal peripheral nervous system,...
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