Article
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2014
Ahsan Habibul, Halpern Jerry, Kibriya Muhammad G, Pierce Brandon L, Tong Lin, Gamazon Eric, McGuire Valerie, Felberg Anna, Shi Jianxin, Jasmine Farzana, Roy Shantanu, Brutus Rachelle, Argos Maria, Melkonian Stephanie, Chang-Claude Jenny, Andrulis Irene, Hopper John L, John Esther M, Malone Kathi, Ursin Giske, Gammon Marilie D, Thomas Duncan C, Seminara Daniela, Casey Graham, Knight Julia A, Southey Melissa C, Giles Graham G, Santella Regina M, Lee Eunjung, Conti David, Duggan David, Gallinger Steve, Haile Robert, Jenkins Mark, Lindor Noralane M, Newcomb Polly, Michailidou Kyriaki, Apicella Carmel, Park Daniel J, Peto Julian, Fletcher Olivia, dos Santos Silva Isabel, Lathrop Mark, Hunter David J, Chanock Stephen J, Meindl Alfons, Schmutzler Rita K, Müller-Myhsok Bertram, Lochmann Magdalena, Beckmann Lars, Hein Rebecca, Makalic Enes, Schmidt Daniel F, Bui Quang Minh, Stone Jennifer, Flesch-Janys Dieter, Dahmen Norbert, Nevanlinna Heli, Aittomäki Kristiina, Blomqvist Carl, Hall Per, Czene Kamila, Irwanto Astrid, Liu Jianjun, Rahman Nazneen, Turnbull Clare, Dunning Alison M, Pharoah Paul, Waisfisz Quinten, Meijers-Heijboer Hanne, Uitterlinden Andre G, Rivadeneira Fernando, Nicolae Dan, Easton Douglas F, Cox Nancy J, Whittemore Alice S
Abstract excerpt
Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 population control women ages ≤ 51 years. The SNPs with smallest P values were examined in a replication set of 3,470 EOBC cases and 5,475 control women. We...
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