Article
Rare coding variants and breast cancer risk: evaluation of susceptibility Loci identified in genome-wide association studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2014
Zhang Yanfeng, Long Jirong, Lu Wei, Shu Xiao-Ou, Cai Qiuyin, Zheng Ying, Li Chun, Li Bingshan, Gao Yu-Tang, Zheng Wei
Abstract excerpt
BACKGROUND: To date, common genetic variants in approximately 70 loci have been identified for breast cancer via genome-wide association studies (GWAS). It is unknown whether rare variants in these loci are also associated with breast cancer risk. METHODS: We investigated rare missense/nonsense variants with minor allele frequency (MAF) ≤5% located in flanking 500 kb of each of the index single-nucleotide...
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