Article
PP2ARts1 is a master regulator of pathways that control cell size.
The Journal of cell biology - 3 Feb 2014
Zapata Jessica, Dephoure Noah, Macdonough Tracy, Yu Yaxin, Parnell Emily J, Mooring Meghan, Gygi Steven P, Stillman David J, Kellogg Douglas R
Abstract excerpt
Cell size checkpoints ensure that passage through G1 and mitosis occurs only when sufficient growth has occurred. The mechanisms by which these checkpoints work are largely unknown. PP2A associated with the Rts1 regulatory subunit (PP2A(Rts1)) is required for cell size control in budding yeast, but the relevant targets are unknown. In this paper, we used quantitative proteome-wide mass spectrometry to identify...
Topics
- Amino Acid Sequence
- Gene Expression Regulation, Fungal
- Metaphase
- Molecular Sequence Data
- Mutation
- Phosphoproteins
- Phosphorylation
- Promoter Regions, Genetic
- Protein Binding
- Protein Phosphatase 2