Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth.

Abstract excerpt

Clb2 is a conserved B-type cyclin essential for mitotic progression in Saccharomyces cerevisiae, with expression tightly regulated at transcriptional and proteolytic levels. However, it remains unclear whether Clb2 protein synthesis is regulated and responsive to cell growth. Here, we show that CLB2 mRNA localizes to the bud via the She2/She3 complex, while Clb2 protein accumulates in the mother nucleus. This...

Topics

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• Cell Cycle
• Cell Nucleus
• Cyclin B
• Gene Expression Regulation, Fungal
• Protein Biosynthesis
• RNA, Messenger