Article
Identification of pathways regulating cell size and cell-cycle progression by RNAi.
Nature - 23 Feb 2006
Björklund Mikael, Taipale Minna, Varjosalo Markku, Saharinen Juha, Lahdenperä Juhani, Taipale Jussi
Abstract excerpt
Many high-throughput loss-of-function analyses of the eukaryotic cell cycle have relied on the unicellular yeast species Saccharomyces cerevisiae and Schizosaccharomyces pombe. In multicellular organisms, however, additional control mechanisms regulate the cell cycle to specify the size of the organism and its constituent organs. To identify such genes, here we analysed the effect of the loss of function of 70%...
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