Identification of pathways regulating cell size and cell-cycle progression by RNAi.

doi:10.1038/nature04469

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Article

Identification of pathways regulating cell size and cell-cycle progression by RNAi.

Nature - 23 Feb 2006

Björklund Mikael, Taipale Minna, Varjosalo Markku, Saharinen Juha, Lahdenperä Juhani, Taipale Jussi

Abstract excerpt

Many high-throughput loss-of-function analyses of the eukaryotic cell cycle have relied on the unicellular yeast species Saccharomyces cerevisiae and Schizosaccharomyces pombe. In multicellular organisms, however, additional control mechanisms regulate the cell cycle to specify the size of the organism and its constituent organs. To identify such genes, here we analysed the effect of the loss of function of 70%...

Topics

Active Transport, Cell Nucleus
Animals
Cell Cycle
Cell Line
Cell Size
Conserved Sequence
Drosophila Proteins
Drosophila melanogaster
Gene Library
Genes, Insect
Humans
Phenotype
Phosphorylation
RNA Interference
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 16496002
DOI: 10.1038/nature04469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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