Article
A retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
BMC cancer - 3 Feb 2014
Blank Susanne, Rachakonda Sivaramakrishna, Keller Gisela, Weichert Wilko, Lordick Florian, Langer Rupert, Springfeld Christoph, Bruckner Thomas, Becker Karen, Kumar Rajiv, Ott Katja
Abstract excerpt
BACKGROUND: Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms for primarily resected and neoadjuvantly treated esophagogastric adenocarcinomas. METHODS: 569...
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