Article
DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy.
Annals of surgical oncology - 1 Sept 2011
Ott Katja, Rachakonda P Sivaramakrishna, Panzram Benjamin, Keller Gisela, Lordick Florian, Becker Karen, Langer Rupert, Buechler Markus, Hemminki Kari, Kumar Rajiv
Abstract excerpt
BACKGROUND: DNA repair plays an important role in chemoresistance to platinum-based therapy, and therefore polymorphisms in the genes may modulate therapeutic response. We assessed 12 polymorphisms in 7 DNA repair genes and 2 polymorphisms in the MTHFR gene for association with disease response a...
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