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Article

The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor-related survival in neoadjuvant treated locally advanced gastric cancer.

International journal of cancer - 15 Dec 2006

Ott Katja, Vogelsang Holger, Marton Noemi, Becker Karen, Lordick Florian, Kobl Michael, Schuhmacher Christoph, Novotny Alexander, Mueller James, Fink Ulrich, Ulm Kurt, Siewert Jörg Rüdiger, Höfler Heinz, Keller Gisela

Abstract excerpt

We evaluated DNA polymorphisms in the thymidylate synthase (TS) and 5,10-methylene-tetrahydrofolate reductase (MTHFR) genes for an association with response and survival in locally advanced gastric cancer treated with 5-FU based preoperative chemotherapy (CTx). DNA of 238 patients (CTx-group: total n = 135, completely resected (R0) n = 102; without CTx: R0 n = 103) was isolated from blood or from nontumorous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16929515
DOI: 10.1002/ijc.22235

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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