Article
Drug resistance of a viral population and its individual intrahost variants during the first 48 hours of therapy.
Clinical pharmacology and therapeutics - 1 Jun 2014
Campo D S, Skums P, Dimitrova Z, Vaughan G, Forbi J C, Teo C G, Khudyakov Y, Lau D T-Y
Abstract excerpt
Using hepatitis C virus (HCV) and interferon (IFN) resistance as a proof of concept, we have devised a new method for calculating the effect of a drug on a viral population, as well as the resistance of the population's individual intrahost variants. By means of next-generation sequencing, HCV va...
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