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Article

Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a Chilean pediatric population.

American journal of hypertension - 1 Mar 2014

Tapia-Castillo Alejandra, Carvajal Cristian A, Campino Carmen, Vecchiola Andrea, Allende Fidel, Solari Sandra, García Lorena, Lavanderos Sergio, Valdivia Carolina, Fuentes Cristobal, Lagos Carlos F, Martínez-Aguayo Alejandro, Baudrand Rene, Aglony Marlene, García Hernán, Fardella Carlos E

Abstract excerpt

BACKGROUND: The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters in a Chilean pediatric cohort. METHODS: Two hundred two normotensive (NT) subjects (aged 4-16...

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Source

Identifiers

PMID: 24487980
DOI: 10.1093/ajh/hpt277

Genes

RAC1
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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