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Article

IL-1β induction ofMUC5ACgene expression is mediated by CREB and NF-κB and repressed by dexamethasone

1 Feb 2014

Abstract excerpt

Chronic airway diseases are characterized by inflammation and mucus overproduction. The MUC5AC mucin gene is upregulated by the proinflammatory cytokine interleukin-1 β (IL-1β) via activation of cAMP response element-binding protein (CREB) in the NCI-H292 cancer cell line and nuclear factor-κB (NF-κB) in the HBE1 transformed cell line, with each transcription factor binding to a cognate cis site in the proximal...

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PMID: 24487386
DOI: 10.1152/ajplung.00347.2013

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