Anti-inflammation: Direct Physical Association and Functional Antagonism Between Transcription Factor NF-KB and the Glucocorticoid Receptor

Abstract excerpt

Glucocorticoids are widely used clinically as anti-inflammatory and immunosuppressive agents. Of all the pharmaceutical approaches to the treatment of asthma, glucocorticoids are undoubtedly the most potent. These effects of glucocorticoids result, to a great extent, from their ability to inhibit cellular release of inflammatory mediators and cytokines. Despite their widespread use, the molecular mechanisms by...

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