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Article

Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions.

Gastroenterology - 1 May 2014

Kang Wonseok, Sung Pil Soo, Park Su-Hyung, Yoon Sarah, Chang Dong-Yeop, Kim Seungtaek, Han Kwang Hyub, Kim Ja Kyung, Rehermann Barbara, Chwae Yong-Joon, Shin Eui-Cheol

Abstract excerpt

BACKGROUND & AIMS: Major histocompatibility complex (MHC) class I-restricted CD8(+) T cells are required for clearance of hepatitis C virus (HCV) infection. MHC class I expression is up-regulated by type I and II interferons (IFNs). However, little is known about the effects of HCV infection on IFN-induced expression of MHC class I. METHODS: We used the HCV cell culture system (HCVcc) with the genotype 2a...

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Identifiers

PMID: 24486950
DOI: 10.1053/j.gastro.2014.01.054
PMCID: PMC4478444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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