Article
Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy - 7 Jun 2017
Zheng Bin, Yin Wei-Na, Suzuki Toru, Zhang Xin-Hua, Zhang Yu, Song Li-Li, Jin Li-Shuang, Zhan Hong, Zhang Hong, Li Jin-Shui, Wen Jin-Kun
Abstract excerpt
The vascular response to pro-atherosclerotic factors is a multifactorial process involving endothelial cells (ECs), macrophages (MACs), and smooth muscle cells (SMCs), although the mechanism by which these cell types communicate with each other in response to environmental cues is yet to be understood. Here, we show that miR-155, which is significantly expressed and secreted in Krüppel-like factor 5...
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