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Article

Lack of centrioles and primary cilia in STIL(-/-) mouse embryos.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

David Ahuvit, Liu Fengying, Tibelius Alexandra, Vulprecht Julia, Wald Diana, Rothermel Ulrike, Ohana Reut, Seitel Alexander, Metzger Jasmin, Ashery-Padan Ruth, Meinzer Hans-Peter, Gröne Hermann-Josef, Izraeli Shai, Krämer Alwin

Abstract excerpt

Although most animal cells contain centrosomes, consisting of a pair of centrioles, their precise contribution to cell division and embryonic development is unclear. Genetic ablation of STIL, an essential component of the centriole replication machinery in mammalian cells, causes embryonic lethality in mice around mid gestation associated with defective Hedgehog signaling. Here, we describe, by focused ion beam...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25486474
DOI: 10.4161/15384101.2014.946830
PMCID: PMC4615128

Genes

STIL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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