Article
Pol II docking and pausing at growth and stress genes in C. elegans.
Cell reports - 13 Feb 2014
Maxwell Colin S, Kruesi William S, Core Leighton J, Kurhanewicz Nicole, Waters Colin T, Lewarch Caitlin L, Antoshechkin Igor, Lis John T, Meyer Barbara J, Baugh L Ryan
Abstract excerpt
Fluctuations in nutrient availability profoundly impact gene expression. Previous work revealed postrecruitment regulation of RNA polymerase II (Pol II) during starvation and recovery in Caenorhabditis elegans, suggesting that promoter-proximal pausing promotes rapid response to feeding. To test this hypothesis, we measured Pol II elongation genome wide by two complementary approaches and analyzed elongation in...
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