Article
Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup.
Retrovirology - 23 May 2017
Bachmann Nadine, Turk Teja, Kadelka Claus, Marzel Alex, Shilaih Mohaned, Böni Jürg, Aubert Vincent, Klimkait Thomas, Leventhal Gabriel E, Günthard Huldrych F, Kouyos Roger
Abstract excerpt
BACKGROUND: Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO regression to viral traits is unclear because the direction of viral transmission-who is the donor (parent) and who is the recipient (offspring)-is typically unknown and viral phylogenies are...
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