Article
Ligand density elicits a phenotypic switch in human neutrophils.
Integrative biology : quantitative biosciences from nano to macro - 1 Mar 2014
Henry Steven J, Crocker John C, Hammer Daniel A
Abstract excerpt
Neutrophils are mediators of innate immunity and motility is critical to their function. We used microcontact printing to investigate the relationship between density of adhesive ligands and the dynamics of neutrophil motility. We show that neutrophils adopt a well-spread morphology without a uropod on moderate densities of adhesion ligand. As density is increased, the morphology switches to a classic amoeboid...
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