Article
Molecular classification of familial non-BRCA1/BRCA2 breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Hedenfalk Ingrid, Ringner Markus, Ben-Dor Amir, Yakhini Zohar, Chen Yidong, Chebil Gunilla, Ach Robert, Loman Niklas, Olsson Håkan, Meltzer Paul, Borg Ake, Trent Jeffrey
Abstract excerpt
In the decade since their discovery, the two major breast cancer susceptibility genes BRCA1 and BRCA2, have been shown conclusively to be involved in a significant fraction of families segregating breast and ovarian cancer. However, it has become equally clear that a large proportion of families segregating breast cancer alone are not caused by mutations in BRCA1 or BRCA2. Unfortunately, despite intensive effort,...
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