Article
EUK-134 ameliorates nNOSμ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Apr 2014
Lawler John M, Kunst Mary, Hord Jeff M, Lee Yang, Joshi Kumar, Botchlett Rachel E, Ramirez Angelo, Martinez Daniel A
Abstract excerpt
Reduced mechanical loading during bedrest, spaceflight, and casting, causes rapid morphological changes in skeletal muscle: fiber atrophy and reduction of slow-twitch fibers. An emerging signaling event in response to unloading is the translocation of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma to the cytosol. We used EUK-134, a cell-permeable mimetic of superoxide dismutase and catalase, to test...
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