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Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study.

Frontiers in endocrinology - 1 Jan 2022

Huang Mingkai, Laina-Nicaise Loum-Davadi, Zha Lingfeng, Tang Tingting, Cheng Xiang

Abstract excerpt

Objective: We aimed to evaluate the causal effect of type 2 diabetes mellitus (T2DM) and glycemic traits on the risk of a wide range of cardiovascular diseases (CVDs) and lipid traits using Mendelian randomization (MR). Methods: Genetic variants associated with T2DM, fasting glucose, fasting insulin, and hemoglobin A1c were selected as instrumental variables to perform both univariable and multivariable MR...

Topics

Blood Glucose
Cardiovascular Diseases
Cholesterol, HDL
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Humans
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35528012
DOI: 10.3389/fendo.2022.840579
PMCID: PMC9072667

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