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Article

Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

28 Jan 2014

Abstract excerpt

BACKGROUND: Jumonji domain-containing protein 2B (JMJD2B), directly targeted by hypoxia-inducible factor 1α, maintains the histone methylation balance important for the transcriptional activation of many oncogenes. Jumonji domain-containing protein 2B has been implicated in colorectal cancer (CRC) progression; however, the mechanism remains unclear. METHODS: Immunofluorescence and western blotting detected...

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Share to Autophagy in Disease and Therapy
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PMID: 24473398
DOI: 10.1038/bjc.2013.808

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