Article
GSTA1*-69C/T and GSTO2*N142D as asthma- and allergy-related risk factors in Italian adult patients.
Clinical and experimental pharmacology & physiology - 1 Mar 2014
Piacentini Sara, Polimanti Renato, Iorio Andrea, Cortesi Maurizio, Papa Fabrizio, Rongioletti Mauro, Liumbruno Giancarlo M, Manfellotto Dario, Fuciarelli Maria
Abstract excerpt
1. Asthma and allergies are characterized by variable and subjective symptoms influenced by many genes, molecular mechanisms and environmental factors. The presence of inflammation and oxidative stress in the airways are important biochemical features of asthma and respiratory allergies. Glutathione S-transferase (GSTs) enzymes play an important role in cellular protection against inflammation, and functional...
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