NOTCH gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN).

doi:10.1007/s00432-022-04064-4

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Article

NOTCH gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN).

Journal of cancer research and clinical oncology - 1 Oct 2022

Kajiwara Takeshi, Nishina Tomohiro, Nakasya Akio, Yamashita Natsumi, Yamashita Riu, Nakamura Yoshiaki, Shiozawa Manabu, Yuki Satoshi, Taniguchi Hiroya, Hara Hiroki, Ohta Takashi, Esaki Taito, Shinozaki Eiji, Takashima Atsuo, Moriwaki Toshikazu, Denda Tadamichi, Ohtsubo Koushiro, Sunakawa Yu, Horita Yosuke, Kawakami Hisato, Kato Takeshi, Satoh Taroh, Ando Koji, Mizutani Tomonori, Yasui Hisateru, Goto Masahiro, Okuyama Hiroyuki, Yamazaki Kentaro, Yoshino Takayuki, Hyodo Ichinosuke

Abstract excerpt

PURPOSE: Activated Notch receptor signaling has been implicated in tumor growth and progression in colorectal cancer (CRC). However, the pathogenic relevance of NOTCH gene alterations remains unclear. The aim of this study was to clarify mutational landscapes and assess their clinical significance in patients with metastatic CRC. METHODS: Pre-chemotherapy tumor tissues obtained from 1154 metastatic CRC patients...

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PMID: 35622165
DOI: 10.1007/s00432-022-04064-4

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