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Article

Neutralizing antibodies can initiate genome release from human enterovirus 71

27 Jan 2014

Abstract excerpt

Antibodies were prepared by immunizing mice with empty, immature particles of human enterovirus 71 (EV71), a picornavirus that causes severe neurological disease in young children. The capsid structure of these empty particles is different from that of the mature virus and is similar to "A" particles encountered when picornaviruses recognize a potential host cell before genome release. The monoclonal antibody...

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PMID: 24469789
DOI: 10.1073/pnas.1320624111

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