Article
Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps.
PloS one - 1 Jan 2013
Ku Zhiqiang, Ye Xiaohua, Huang Xulin, Cai Yicun, Liu Qingwei, Li Yan, Su Zhiguo, Huang Zhong
Abstract excerpt
BACKGROUND: Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease, which has been prevalent in Asia-Pacific regions, causing significant morbidity and mortality in young children. Antibodies elicited by experimental EV71 vaccines could neutralize infection in vitro and passively protect animal models from lethal challenge, indicating that neutralizing antibodies play an essential role...
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