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Article

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.

DNA repair - 1 Mar 2012

Fujinaka Yoshihiko, Matsuoka Kazuaki, Iimori Makoto, Tuul Munkhbold, Sakasai Ryo, Yoshinaga Keiji, Saeki Hiroshi, Morita Masaru, Kakeji Yoshihiro, Gillespie David A, Yamamoto Ken-Ichi, Takata Minoru, Kitao Hiroyuki, Maehara Yoshihiko

Abstract excerpt

5-Fluorouracil (5-FU) has long been a mainstay antimetabolite chemotherapeutic drug for the treatment of major solid tumors, particularly colorectal cancer. 5-FU is processed intracellularly to yield active metabolites that compromise RNA and DNA metabolism. However, the mechanisms responsible for its cytotoxicity are not fully understood. From the phenotypic analysis of mutant chicken B lymphoma DT40 cells, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22188649
DOI: 10.1016/j.dnarep.2011.11.005

Genes

ATR
BRCA2
UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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