Article
The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.
PloS one - 1 Jan 2014
Xiang Yang, Ma Long, Wu Weidong, Liu Wei, Li Yongguang, Zhu Xia, Wang Qian, Ma Jinfeng, Cao Mingqin, Wang Qian, Yao Xuemei, Yang Lei, Wubuli Atikaimu, Merle Corinne, Milligan Paul, Mao Ying, Gu Jiayi, Xin Xiumei
Abstract excerpt
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.