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Article

A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.

PloS one - 1 Jan 2014

Millán-Uclés Africa, Díaz-Castro Blanca, García-Flores Paula, Báez Alicia, Pérez-Simón José Antonio, López-Barneo José, Piruat José I

Abstract excerpt

Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hypoxia-inducible factor 1α (Hif1α) at normal oxygen tension, a theory referred to as "pseudo-hypoxic drive". Other...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24465590
DOI: 10.1371/journal.pone.0085528
PMCID: PMC3896393

Genes

SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.PMID 24465590Read ↗

Cells silenced for SDHB expression display characteristic features of the tumor phenotype.Semantic proximity Read ↗

A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− ratsSemantic proximity Read ↗

Identification of a Signaling Axis HIF-1α/MicroRNA-210/ISCU Independent of SDH Mutation That Defines a Subgroup of Head and Neck ParagangliomasSemantic proximity Read ↗

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletionSemantic proximity Read ↗

Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.Semantic proximity Read ↗

The role of complex II in disease.Semantic proximity Read ↗

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in PheochromocytomasSemantic proximity Read ↗

Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma.Semantic proximity Read ↗

Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.Semantic proximity Read ↗

Transcription Association of <i>VHL</i> and <i>SDH</i> Mutations Link Hypoxia and Oxidoreductase Signals in PheochromocytomasSemantic proximity Read ↗

Preclinical evaluation of targeted therapies in Sdhb-mutated tumors.Semantic proximity Read ↗

Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related PheochromocytomasSemantic proximity Read ↗

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