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Article

Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma.

PloS one - 24 Nov 2009

Bayley Jean-Pierre, van Minderhout Ivonne, Hogendoorn Pancras C W, Cornelisse Cees J, van der Wal Annemieke, Prins Frans A, Teppema Luc, Dahan Albert, Devilee Peter, Taschner Peter E M

Abstract excerpt

BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the electron transport chain. Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors paraganglioma (PGL) and phe...

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Share to Gene Expression Regulation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19956719
DOI: 10.1371/journal.pone.0007987
PMCID: PMC2776493

Genes

SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19956719-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma.PMID 19956719Read ↗

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SDH mutations in cancer.Semantic proximity Read ↗

A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features.Semantic proximity Read ↗

Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effect.Semantic proximity Read ↗

A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.Semantic proximity Read ↗

Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?Semantic proximity Read ↗

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SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas.Semantic proximity Read ↗

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