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Article

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

25 Jul 2005

Abstract excerpt

Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD). A transcription profile of...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 16103922
DOI: 10.1371/journal.pgen.0010008

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A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in PheochromocytomasPMID 16103922Read ↗

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The Role of Immunohistochemistry and Molecular Analysis of Succinate Dehydrogenase in the Diagnosis of Endocrine and Non-Endocrine Tumors and Related SyndromesSemantic proximity Read ↗

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