Transcription Association of <i>VHL</i> and <i>SDH</i> Mutations Link Hypoxia and Oxidoreductase Signals in Pheochromocytomas

Abstract excerpt

Pheochromocytomas and paragangliomas are neural-crest-derived tumors that arise from mutations in RET, VHL, NF1, and in the genes-encoding succinate dehydrogenase (SDH) subunits B (SDHB), C (SDHC), and D (SDHD). Despite their genetic diversity, these tumors cannot be clearly distinguished on the basis of their primary mutation. We recently identified two major transcriptional programs embedded within familial and...

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