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Article

Prevalence and Clinical Characteristics of PDX1 Variant Induced Diabetes in Chinese Early-Onset Type 2 Diabetes.

The Journal of clinical endocrinology and metabolism - 17 Nov 2023

Lian Hong, Gong Siqian, Li Meng, Wang Xirui, Wang Fang, Cai Xiaoling, Liu Wei, Luo Yingying, Zhang Simin, Zhang Rui, Zhou Lingli, Zhu Yu, Ma Yumin, Ren Qian, Zhang Xiuying, Chen Jing, Chen Ling, Wu Jing, Gao Leili, Zhou Xianghai, Li Yufeng, Zhong Liyong, Han Xueyao, Ji Linong

Abstract excerpt

CONTEXT: Maturity-onset diabetes of the young 4 (MODY4) is caused by mutations of PDX1; its prevalence and clinical features are not well known. OBJECTIVE: This study aimed to investigate the prevalence and clinical characteristics of MODY4 in Chinese people clinically diagnosed with early-onset type 2 diabetes (EOD), and to evaluate the relationship between the PDX1 genotype and the clinical phenotype. METHOD:...

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PMID: 37279936
DOI: 10.1210/clinem/dgad303

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