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Article

FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors.

Molecular cancer research : MCR - 1 Apr 2014

Megison Michael L, Gillory Lauren A, Stewart Jerry E, Nabers Hugh C, Mrozcek-Musulman Elizabeth, Beierle Elizabeth A

Abstract excerpt

UNLABELLED: Despite the tremendous advances in the treatment of childhood kidney tumors, there remain subsets of pediatric renal tumors that continue to pose a therapeutic challenge, mainly malignant rhabdoid kidney tumors and nonosseous renal Ewing sarcoma. Children with advanced, metastatic, or relapsed disease have a poor disease-free survival rate. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase...

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Identifiers

PMID: 24464916
DOI: 10.1158/1541-7786.MCR-13-0505
PMCID: PMC3989502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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