Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

1 Mar 2010

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumor of childhood. Focal adhesion kinase (FAK) is an intracellular kinase that regulates both cellular adhesion and apoptosis. FAK is overexpressed in a number of human tumors including neuroblastoma. Previously, we have shown that the MYCN oncogene, the primary adverse prognostic indicator in neuroblastoma, regulates the expression of FAK in neuroblastoma. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Cellular Mechanics and Interactions
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20160475
DOI: 10.4161/cc.9.5.10936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaPMID 20160475Read ↗

N-MYC Regulates Focal Adhesion Kinase Expression in Human NeuroblastomaSemantic proximity Read ↗

FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors.Semantic proximity Read ↗

FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeuticsSemantic proximity Read ↗

Focal Adhesion Kinase Expression in Human Neuroblastoma: Immunohistochemical and Real-time PCR AnalysesSemantic proximity Read ↗

FAK signaling in human cancer as a target for therapeuticsSemantic proximity Read ↗

Understanding the Roles of FAK in CancerSemantic proximity Read ↗

Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor.Semantic proximity Read ↗

Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis.Semantic proximity Read ↗

Control of axonal branching and synapse formation by focal adhesion kinase.Semantic proximity Read ↗

Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.Semantic proximity Read ↗

Abundant Focal Adhesion Kinase Causes Aberrant Neuronal Migration Via Its Phosphorylation at Tyr925.Semantic proximity Read ↗

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.