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T‐cell activation RhoGTPase‐activating protein plays an important role in TH17‐cell differentiation

2 May 2017

Abstract excerpt

T‐cell activation RhoGTPase‐activating protein (TAGAP) is a GTPase‐activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome‐wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, including psoriasis, rheumatoid arthritis, Crohn's disease, celiac disease and multiple sclerosis....

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PMID: 28462950
DOI: 10.1038/icb.2017.27

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