Article
TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.
Molecular oncology - 1 May 2014
Győrffy Balázs, Bottai Giulia, Lehmann-Che Jacqueline, Kéri György, Orfi László, Iwamoto Takayuki, Desmedt Christine, Bianchini Giampaolo, Turner Nicholas C, de Thè Hugues, André Fabrice, Sotiriou Christos, Hortobagyi Gabriel N, Di Leo Angelo, Pusztai Lajos, Santarpia Libero
Abstract excerpt
Breast cancers (BC) carry a complex set of gene mutations that can influence their gene expression and clinical behavior. We aimed to identify genes driven by the TP53 mutation status and assess their clinical relevance in estrogen receptor (ER)-positive and ER-negative BC, and their potential as targets for patients with TP53 mutated tumors. Separate ROC analyses of each gene expression according to TP53...
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