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Article

TTK/hMPS1 Is an Attractive Therapeutic Target for Triple-Negative Breast Cancer

20 May 2013

Abstract excerpt

Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potential therapeutic targets, we searched for protein kinases that are overexpressed in human TNBC biopsies and whose silencing in TNBC cell lines causes cell death. A...

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PMID: 23700430
DOI: 10.1371/journal.pone.0063712

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