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Article

Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population.

Birth defects research. Part A, Clinical and molecular teratology - 1 Nov 2010

Bufalino Andreia, Ribeiro Paranaíba Lívia Máris, Nascimento de Aquino Sibele, Martelli-Júnior Hercílio, Oliveira Swerts Mario Sergio, Coletta Ricardo D

Abstract excerpt

BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for...

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Source

Identifiers

PMID: 20890936
DOI: 10.1002/bdra.20732

Genes

MTHFR
MTHFD1
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population.PMID 20890936Read ↗

Two SNPs rs1801133 and rs1801394 in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palateSemantic proximity Read ↗

SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.Semantic proximity Read ↗

Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate developmentSemantic proximity Read ↗

MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.Semantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate.Semantic proximity Read ↗

Increased susceptibility for nonsyndromic cleft lip with or without cleft palate by SLC19A1 80G>A genetic variation.Semantic proximity Read ↗

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