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Article

Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice.

PloS one - 1 Jan 2014

Lau Janet, Zhou Qiang, Sutton Susan E, Herman Ann E, Schmedt Christian, Glynne Richard

Abstract excerpt

AIM/HYPOTHESIS: Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D). Imatinib inhibits c-Abl, c-Kit, and PDGFRs. Next-generation tyrosine kinase inhibitors for T1D treatment shoul...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24454763
DOI: 10.1371/journal.pone.0084900
PMCID: PMC3893161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24454763-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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