Article
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Diabetes - 1 Jan 2006
Lee Chul-Ho, Chen Yi-Guang, Chen Jing, Reifsnyder Peter C, Serreze David V, Clare-Salzler Michael, Rodriguez Michelle, Wasserfall Clive, Atkinson Mark A, Leiter Edward H
Abstract excerpt
Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin receptor (LEPR) mutation (designated Lepr(db-5J)) producing juvenile obesity, hyperglycemia, hyperinsulinemia, and hyperleptinemia. This early type 2 diabetes syndrome suppressed intra-islet insulitis and permitted spontaneous diabetes remission. No significant differences in plasma corticosterone, splenic CD4(+) or...
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