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Article

Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.

Cancer cell - 4 Aug 2009

Oravecz-Wilson Katherine I, Philips Steven T, Yilmaz Omer H, Ames Heather M, Li Lina, Crawford Brendan D, Gauvin Alice M, Lucas Peter C, Sitwala Kajal, Downing James R, Morrison Sean J, Ross Theodora S

Abstract excerpt

Despite remarkable responses to the tyrosine kinase inhibitor imatinib, CML patients are rarely cured by this therapy perhaps due to imatinib refractoriness of leukemia-initiating cells (LICs). Evidence for this is limited because of poor engraftment of human CML-LICs in NOD-SCID mice and nonphys...

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Identifiers

PMID: 19647224
DOI: 10.1016/j.ccr.2009.06.007
PMCID: PMC2763369

Genes

HIP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19647224-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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