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Article

A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.

The Journal of biological chemistry - 14 Mar 2014

Shao Di, Fry Jessica L, Han Jingyan, Hou Xiuyun, Pimentel David R, Matsui Reiko, Cohen Richard A, Bachschmid Markus M

Abstract excerpt

Sirtuin-1 (SirT1), a member of the NAD(+)-dependent class III histone deacetylase family, is inactivated in vitro by oxidation of critical cysteine thiols. In a model of metabolic syndrome, SirT1 activation attenuated apoptosis of hepatocytes and improved liver function including lipid metabolism. We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress...

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Identifiers

PMID: 24451382
DOI: 10.1074/jbc.M113.520403
PMCID: PMC3953247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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