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Article

USP25 regulates Wnt signaling by controlling the stability of tankyrases.

Genes & development - 15 May 2017

Xu Daichao, Liu Jianping, Fu Tao, Shan Bing, Qian Lihui, Pan Lifeng, Yuan Junying

Abstract excerpt

Aberrant activation of the Wnt signaling pathway plays an important role in human cancer development. Wnt signaling is negatively regulated by Axin, a scaffolding protein that controls a rate-limiting step in the destruction of β-catenin, the central activator of the Wnt pathway. In Wnt-stimulated cells, Axin is rapidly modified by tankyrase-mediated poly(ADP-ribosyl)ation, which promotes the proteolysis of Axin...

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Share to Ankyrin Repeat
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28619731
DOI: 10.1101/gad.300889.117
PMCID: PMC5495119

Genes

USP25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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